What are GI side effects?

GI (gastrointestinal) side effects — nausea, vomiting, diarrhea, constipation, reflux — are the most common GLP-1 side effects and usually cluster around dose increases during titration.

GI (gastrointestinal) side effects — nausea, vomiting, diarrhea, constipation, reflux — are the most common GLP-1 side effects and usually cluster around dose increases during titration. GLP-1 medications work in part by slowing the stomach (delayed gastric emptying). That's why food sits longer, fullness lasts longer, and the GI tract reports more symptoms during the first weeks of each new dose. Most GI side effects fade within 2–4 weeks of a step-up. Tactics that help: smaller meals, lower-fat meals, adequate fiber and water, and pausing at the current dose if symptoms are severe. Severe vomiting, severe abdominal pain, or signs of dehydration warrant calling your prescriber — these are not side effects to push through.

Related pages

• Wegovy nausea relief
• Zepbound constipation
• Ozempic side effects in week 1
• GLP-1 glossary

Get the GLPeak app

Download GLPeak on the App Store · Get GLPeak on Google Play