What is GLP-1 titration?

Titration is the slow, stepwise increase of your GLP-1 dose (usually every 4 weeks) that lets your body adjust and minimizes side effects like nausea and vomiting.

Titration is the slow, stepwise increase of your GLP-1 dose (usually every 4 weeks) that lets your body adjust and minimizes side effects like nausea and vomiting. Every FDA-approved GLP-1 starts at a deliberately low dose. Semaglutide titrates from 0.25 mg up in stepwise increases; tirzepatide titrates from 2.5 mg up in 2.5 mg steps. Each step typically lasts at least 4 weeks before the next increase. Going slower is fine — your prescriber can pause a step if side effects are tough. Going faster is not recommended outside of a clinical reason. The titration period is when most GI side effects appear. Tracking which symptoms map to which dose change helps you and your provider decide when to step up.

Related pages

• GLP-1 dosing schedules
• Zepbound dose schedule
• GLP-1 glossary

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