What is GIP?

GIP (glucose-dependent insulinotropic polypeptide) is a second gut hormone that boosts insulin release after meals; combining GIP with GLP-1 activity is what makes tirzepatide more potent than single-receptor drugs.

GIP (glucose-dependent insulinotropic polypeptide) is a second gut hormone that boosts insulin release after meals; combining GIP with GLP-1 activity is what makes tirzepatide more potent than single-receptor drugs. Like GLP-1, GIP is released from the gut when you eat and triggers the pancreas to release insulin. It also affects fat-tissue metabolism. Tirzepatide (Mounjaro, Zepbound) was the first FDA-approved dual GIP/GLP-1 agonist. The investigational drug retatrutide adds a third receptor (glucagon) on top of those two.

Related pages

• Retatrutide tracker
• Ozempic vs Mounjaro
• GLP-1 glossary

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